Important cytokines

Last updated on November 19, 2018 at 17:16

The cytokines and effects which are bolded are the most important.

Cytokine Produced by which cell? Effects
IL-1 Macrophages Inflammatory, acute phase reaction
IL-2 Th1 Induce T-cell proliferation, activate CTL cells, induce Th ⇒ Treg,
IL-3 Th2 Myeloid lineage stimulator
IL-4 Th2, mast cells, NK cells, dendritic cells Anti-inflammatory. Activate mast cells, induce isotype switch to IgG1 and IgE, Induce Th ⇒ Th2
IL-5 Th2 Activate eosinophils
IL-6 Macrophages Inflammatory, acute phase reaction. Induce Th ⇒ T17
IL-7 Survival of B-cells in periphery, proliferation of T-cells in thymus, lymphoid lineage stimulator.
IL-10 APCs, Treg Anti-inflammatory, inhibit effector cells, activate Treg
IL-12 Macrophages, dendritic cells Induce Th ⇒ Th1
IL-13 Th2 Induce isotype switch to IgE
IL-17 Th17 Inflammatory
IL-35 APCs, Treg Anti-inflammatory, inhibit effector cells, activate Treg
TNF Th1 Inflammatory
TGF-β APCs, Treg Anti-inflammatory, inhibit effector cells, activate Treg, induce isotype switch to IgA
IFN Macrophages, Th1 Inflammatory, acute phase reaction, induce isotype switch to IgG1
SCF Stem cell proliferation

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