20. DIC (fibrinthrombi in kidney) (fibrin stain)

Last updated on January 17, 2019 at 17:02

Staining: Weigert (fibrin) stain

Organ: Kidney

Description:

Many parts of the slide are darker, but especially the glomeruli are very dark blue, sometimes black. Some tubules are also dark.

Diagnosis: Disseminated intravascular coagulopathy – phase 1

Causes:

  • Extensive tissue damage
    • Extensive necrosis
    • Sepsis
    • Trauma
    • Burn
    • Heat
    • Acidosis
    • Acute pancreatitis

Theory:

In phase I on DIC, the thrombotic phase, will there be microthrombus and microembolism formation in every organ. In the kidney are the glomerular capillaries especially affected by this.

Some tubules also appear to be fibrin-positive, however this is a false positive result. There is no fibrin inside the tubule cells.

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19. Thrombus and postmortem blood clot

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21. Central haemorrhagic necrosis

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