6. Acute pancreatitis – adiponecrosis

Last updated on January 17, 2019 at 16:50

Staining: HE

Organ: Pancreas

Description:

We can see normal acinar cells. There are paler areas showing necrosis. We can also see neutrophils and RBCs.

Diagnosis: Acute pancreatitis with adiponecrosis

Theory:

Acute pancreatitis occurs when there is a blockage of the pancreatic duct, causing congestion that leads to pancreatic enzymes being activated inside the pancreatic parenchyme. These activated enzymes will then digest the pancreas, causing an acute inflammation.

Causes for pancreatic duct blockage can be:

  • Bile stone
  • Alcohol abuse (activates Oddi sphincter constriction, viscous pancreatitic secretion)
  • Hypercalcemia
  • Hyperlipidemia
  • Chemotherapy
  • Tumor

Acute pancreatitis has two phases. The first is the edematous phase and the second phase is the haemorrhagic phase. 80% of cases stop in the first phase, however it is the second phase that is life-threatening. It can cause sepsis, cardiac failure and ARDS, the latter of which can cause respiratory failure.

Neutrophils are present because there is an acute inflammation, while the RBCs shows that this slide is from the haemorrhagic phase of acute pancreatitis. The RBCs are released from the vessels as the vessels are digested by the pancreatic enzymes.

I wasn’t in the class when we went through this slide, so I don’t really know the detailsSorry.

Password-protected images

These images are password-protected due to copyright concerns. Please verify with a password to unlock the content. If you are a medical student in Pécs or feel like you should have access to the content for any other reason, send me an e-mail.


Previous page:
5. Encephalomalacia alba

Next page:
7. Parenchymal degeneration in kidney

Leave a Reply

Only the "Comment" field must be filled in. It is not compulsory to fill out your name; you can remain anonymous. Do not fill out e-mail or website; if you do, your comment will not be published.