7. Parenchymal degeneration in kidney

Last updated on January 17, 2019 at 16:51

Staining: HE

Organ: Kidney

Description:

We can see “cloudy swelling”, the tubular cells are swelled and no longer has the normal morphology. This degeneration can be seen in the whole slide. The swelling comes from transparent vacuoles inside the cytoplasm.

Diagnosis: Parenchymal degeneration

Theory:

The morphological change called cloudy swelling is actually hydropic or vacuolar degeneration. Hydropic degeneration is the first manifestation of almost all forms of cellular injury. It is always reversible and is caused by how the injury disturbs the cells ability to maintain correct ion concentrations, causing them to take in water and swell.

A cause of hydropic degeneration in the kidney can be cardiac failure. When the heart fails to maintain the cardiac output, all organs will be hypoperfused, which initiates the usual cell injury changes (hypoxia, glycolysis, less ATP.) If the cell injury is maintained for a long time, or the lack of ATP becomes too severe, the cell will die by necrosis.

Password-protected images

These images are password-protected due to copyright concerns. Please verify with a password to unlock the content. If you are a medical student in Pécs or feel like you should have access to the content for any other reason, send me an e-mail.


Previous page:
6. Acute pancreatitis - adiponecrosis

Next page:
8. Steatosis hepatis

Leave a Reply

Only the "Comment" field must be filled in. It is not compulsory to fill out your name; you can remain anonymous. Do not fill out e-mail or website; if you do, your comment will not be published.