Staining: HE and PAS
Organ: Lymph node (not recognizable)
No healthy lymph node tissue is visible. The tumor cells form no structures (like glands or nests). The cells are large and show severe atypia/pleiomorphism, almost anaplastic. The cells resemble centroblasts and are therefore said to be centroblastic in appearance or centroblastoid. There is high mitotic activity (many mitotic figures).
On PAS staining are PAS-positive inclusion bodies in the cytoplasm and nuclei visible, so called Russell bodies and Dutcher bodies, respectively. These inclusion bodies are comprised of immunoglobulin.
Diagnosis: Diffuse large B-cell lymphoma.
- Primary type: mutations in
- Secondary type: Richter transformation from CLL, MZL or FL
Necrosis is also a common histological finding in DLBCL but it can’t be seen here.
17. CLL or SLL infiltration in lymph node
19. Hodgkin lymphoma