24. Prion disease, spongioform encephalopathy

Staining: HE

Organ: Brain

Description:

There is a small region of the grey matter where there are “holes” between neurons. Some vessels resemble these holes.

Diagnosis: Prion disease

Causes:

  • Infection by prions

Theory:

As prions accumulate inside the neurons will the neurons commit apoptosis, which leaves behind small holes between the healthy cells.

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23. Senile plaques and neurofibrillar degeneration

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25. Subacute granulomatous thyreoiditis (De Quervain)

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