49. Giant cell tumor of bone (osteoclastoma)

Staining: HE

Organ: Bone tumor sampled by curettage

Description:

The purplish things are pieces of the tumor. The pinkish things are not.

The tumor pieces are comprised of two types of cell. There are osteoclast-type giant cells, which have large eosinophilic cytoplasm and many nuclei. These cells are not neoplastic; they are reactive cells.

The cells that are between the giant cells are the neoplastic cells. These cells are primitive mesenchymal cells with poorly defined cytoplasm.

Diagnosis: Giant cell tumor of bone

Risk factors:

  • Age 20 – 45

Theory:

The old name for this tumor is “osteoclastoma”.

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