6. Rectal adenocarcinoma

Last updated on February 17, 2019 at 12:09

Staining: HE

Organ: Rectum

Description:

On the leftmost part of the slide is the tissue normal and healthy.

In the middle of the tumor can we see a large ulceration. The tumor invades beyond the subserosal fat tissue. The tumor cells only show mild pleiomorphism and they do form tubular structures. The neostroma is hypercellular.

In the upper right corner of the slide can we see some lymphovascular invasion.

Diagnosis: Rectal adenocarcinoma T3

Risk factors:

  • Inflammatory bowel disease
  • Adenomatous polyps
  • Western diet
  • Smoking, alcohol

Theory:

This tumor invades beyond the muscle and even the subserosa, which gives it the staging T3. The tumor cells only show mild pleiomorphism and they produce abnormal tubular/glandular structures, indicating that the tumor is well-differentiated and therefore low-grade.

Some of the tubular structures contain dirty necrosis. The tumor is of ulcerative type as we can see a large ulceration in the tumor. The neostroma is hypercellular.

Colorectal cancer is commonly associated with mutations in the APC gene or with microsatellite instability.

The lymphovascular invasion may in fact be a metastatic lymph node and not a vessel, however we see no lymphoid tissue so a lymphovascular invasion is more likely.

Password-protected images

These images are password-protected due to copyright concerns. Please verify with a password to unlock the content. If you are a medical student in Pécs or feel like you should have access to the content for any other reason, send me an e-mail.


Previous page:
5. Carcinoid of the appendix

Next page:
7. HBs antigen positivism (Shikata orcein)

Leave a Reply

Only the "Comment" field must be filled in. It is not compulsory to fill out your name; you can remain anonymous. Do not fill out e-mail or website; if you do, your comment will not be published.