14. Focal nodular hyperplasia

Organ: Liver

Description:

On the front of the preparation can we see a well-circumscribed brownish lesion. The lesion has a central scar.

On the back of the preparation can we see a poorly circumscribed greyish lesion.

Diagnosis: Front: Focal nodular hyperplasia. Back: Liver metastasis

Causes:

  • Focal nodular hyperplasia:
    • Oral contraceptive use

Theory:

This preparation contains two different, unrelated lesions. On the front is the lesion of a focal nodular hyperplasia (FNH). FNH is the second most prevalent benign tumor of the liver. It has no malignant potential and is normally asymptomatic, so it’s usually not treated. FNH produces a lesion with a characteristic star-shaped scar in the centre.

The second lesion is on the back and is a liver metastasis.

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13. Macronodular (postnecrotic) cirrhosis

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15. Hepatocellular carcinoma

2 thoughts on “14. Focal nodular hyperplasia”

  1. Hey, I just wanted to say that you can’t really call this a neoplasm or a benign tumor, since it it’s hyperplasia. The definition of a tumor is that all the cells develop from one cell.

    1. You’re not wrong, but every source I can find except Robbins calls it a tumor, so I don’t see any harm in using that term. It is written in the theoretical topic that it is not a true neoplasm.

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