64. Disorders of tubular functions

Last updated on November 29, 2019 at 13:13

The tubules work hard

Despite there being 180 L of ultrafiltrate produced each day is the urine output only 1 – 1.5 L/day, indicating that the tubules must do a lot of reabsorption. The urine also has a very different composition from the ultrafiltrate. When the tubules dysfunction will both the quantity and the quality of the urine be different.

This is a good time to introduce some new (or not) terms. Specific gravity is a measure of how concentrated the urine is compared to pure water. It’s calculated like this:

From this formula can we understand that if the concentration of your urine is the same as the concentration of pure water would the specific gravity be 1. However, because there are always some molecules or ion in urine (urine cannot be pure water) will the concentration of urine always be higher than the concentration of water, so the number will always be above 1. If your urine was just pure water would the specific gravity be 1.000. As we said, that’s impossible. The absolute lowest specific gravity of urine possible is 1.001, meaning that the urine is just barely more concentrated than pure water (just 0.1% more concentrated than water).

The normal value for specific gravity of urine is 1.010 – 1.012 if a person is well hydrated, but in pathological conditions or overhydration can it be as low as 1.001 (but never lower!). In exsiccosis can the specific gravity be around 1.030 – 1.035. There is no upper roof for specific gravity, as it can be above 1.035 in e.g. diabetes mellitus.

Hyposthenuria is the condition where the specific gravity is low, but we will get back to that later.

Primary tubular dysfunctions

We have both congenital and acquired primary tubulopathies. They are primary in the sense that there is no other renal damage in the background (at least in the early phase).

Renal tubular acidosis (RTA) is a condition where the tubules can’t excrete H+, so the kidney can’t acidify the urine, causing acidosis. It can have both congenital and acquired causes. There are three (important) types.

  • RTA type 1 where the H+ excretion in the distal tubules is defective
  • RTA type 2 where the bicarbonate reabsorption in the proximal tubules is decreased
  • RTA type 4 where there is hypoaldosteronism or tubular cells are resistant to aldosterone. Hyperkalaemia also occurs.

See topic 76 for more details on RTA I and II.

It’s still uncertain if what was originally considered RTA type 3 actually exists, which is why the types are so weird. We’ll come back to this in the acidosis topics.

Renal diabetes insipidus can also be either congenital or acquired. It occurs when the distal and collecting tubule cells are AVP resistant, making them unable to concentrate the urine. A lot of water is lost in the urine.

Tubular hypoxia, whether due to hypoxaemia, ischaemia or transplant rejection will cause non-specific tubular damage with hyposthenuric polyuria.

Some toxins and drugs can cause tubulointerstitial nephritis, like mushroom toxins, antifreeze, drug effects and hypersensitivity reactions. SNGFR will increase in the unaffected nephrons, damaging them as well.

Certain metabolic disorders, like uric acid, oxalate, hypokalaemia and hypercalcaemia can damage the tubules. Hypercalcaemia can cause metastatic calcification of the tubules, and can occur from paraneoplastic syndromes.

Autoimmune diseases like SLE or Sjögren syndrome can damage the tubules.

Fibrosis can compress and damage the tubules.

Renal glucosuria is a congenital condition where the person has limited ability to reabsorb glucose in the proximal tubule. This may cause osmotic diuresis.

Renal aminoaciduria is another congenital condition where the amino acid reabsorption capacity is reduced. It usually causes cysteine stones and amino acid deficiencies.

Renal phosphaturia may develop if there is hyperparathyroidism or if the tubules are too sensitive to PTH. This may cause rickets (bone weakness).

Fanconi syndrome is a congenital or acquired disorder characterised by glucosuria, aminoaciduria, phosphaturia and bicarbonate loss.

Secondary tubular dysfunctions

The glomerular filtration rate (GFR) counts the sum of SNGFR for all functional tubules in both kidneys. It’s therefore a measure of the total kidney filtration.

These dysfunctions occur because of a primary problem with filtration, which causes the tubules to have to adapt and compensate for the filtration problem.

If SNGFR is low (due to slight hypovolaemia or decreased RBF) the filtrate will flow slower through the tubules, allowing the tubules more time to reabsorb salts and fluid. This causes more fluid to be reabsorbed into the plasma and less urine to be produced, which normalizes the plasma volume.

In cases where the number of functioning nephrons decreases the SNGFR of the remaining nephrons increases to compensate. Fewer functional nephrons but increased filtration through them means that the GFR of the kidney isn’t reduced. However, the SNGFR can’t increase indefinitely so there will reach a point where as more nephrons are lost the GFR will eventually drop as well.

When the SNGFR is high, if the same amount of tubular reabsorption was performed as when the SNGFR was normal, a lot of water and fluid would be excreted and lost. So, the tubules must also be increase the reabsorption of certain salts and water to avoid losing them. However, some but not all of the excess filtrate must be reabsorbed. If all the excess filtrate were absorbed it would be meaningless to increase the SNGFR, as all the extra filtrate would be reabsorbed.

So the tubules must adapt their reabsorption and secretion when the SNGFR is increased so that they don’t reabsorb too much. If they reabsorbed too much the plasma concentration of salts would increase. If they reabsorb too little a lot of fluid and salts would be lost. The tubules must therefore adapt their reabsorption. However, the tubules adapt to this differently for different substances, and not at all for certain substances.

The tubules adapt the reabsorption of Na+ and K+ very well, meaning that the tubules reabsorbs less of them as the SNGFR increases. This keeps the Na+ and K+ levels in the plasma stable. This adaptation is due to the kidneys producing natriuretic substances and aldosterone to increase the excretion of the salts. This adaptation is so good that the plasma concentration of these salts doesn’t increase until the GFR is almost 0.

H+ and phosphate are not as well adapted, but still relatively well adapted. When GFR decreases PTH will be produced, which increases excretion of phosphate. This adaptation is still good, so the plasma concentration of H+ and phosphate doesn’t increase before the GFR is at 25% of the normal value.

The reabsorption and secretion of urea and creatinine is not well adapted at all, so when the GFR drops to just 50% of its normal value urea and creatinine will start to accumulate in the blood.

This graph shows the plasma concentration of different substances in correlation with the GFR. From this figure we can understand that hypernatraemia and hyperkalaemia only occurs when GFR is almost zero, while azotaemia (urea and creatinine in blood) occurs already when GFR drops to half its normal value.

Magnification is an important phenomenon in cases where the GFR is decreased, and it’s related to this tubular adaptation. The phenomenon states that the Na+ excretion will always be proportional to the reduction in GFR, so that if the GFR is 10x lower than normal the Na+ excretion will be adjusted to be 10x higher than normal This maintains the correct plasma Na+ concentration. Magnification It’s basically the same as tubular adaption, I can’t see the difference.

Previous page:
63. Pathophysiology of glomerular filtration

Next page:
65. Proteinuria

2 thoughts on “64. Disorders of tubular functions”

  1. Hello!
    One thing i do not understand, when we have decreased RBF say due to hypovolemia, the kidneys try to increase Na+ and water retention? i dont quite understand the last part with magnification, when GFR decreases, then Na excretion incresases, isnt that kind of counterproductive in regard to the hypovolemia?

    1. When the RBF decreases the SNGFR decreases. The magnification phenomenon is about when the SNGFR increases, due to nephron loss in chronic renal failure.

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