Page created on April 24, 2018. Last updated on December 18, 2024 at 16:55
The cytokines and effects which are bolded are the most important.
| Cytokine | Produced by which cell? | Effects |
| IL-1 | Macrophages | Inflammatory, acute phase reaction |
| IL-2 | Th1 | Induce T-cell proliferation, activate CTL cells, induce Th ⇒ Treg, |
| IL-3 | Th2 | Myeloid lineage stimulator |
| IL-4 | Th2, mast cells, NK cells, dendritic cells | Anti-inflammatory. Activate mast cells, induce isotype switch to IgG1 and IgE, Induce Th ⇒ Th2 |
| IL-5 | Th2 | Activate eosinophils |
| IL-6 | Macrophages | Inflammatory, acute phase reaction. Induce Th ⇒ T17 |
| IL-7 | Survival of B-cells in periphery, proliferation of T-cells in thymus, lymphoid lineage stimulator. | |
| IL-10 | APCs, Treg | Anti-inflammatory, inhibit effector cells, activate Treg |
| IL-12 | Macrophages, dendritic cells | Induce Th ⇒ Th1 |
| IL-13 | Th2 | Induce isotype switch to IgE |
| IL-17 | Th17 | Inflammatory |
| IL-35 | APCs, Treg | Anti-inflammatory, inhibit effector cells, activate Treg |
| TNF-α | Th1 | Inflammatory |
| TGF-β | APCs, Treg | Anti-inflammatory, inhibit effector cells, activate Treg, induce isotype switch to IgA |
| IFN-γ | Macrophages, Th1 | Inflammatory, acute phase reaction, induce isotype switch to IgG1 |
| SCF | Stem cell proliferation |