Page created on May 11, 2018. Last updated on July 11, 2020 at 14:07
It’s important to note that the effect of PKA on Aquaporin 2 and K+-channel is not activated by glucagon or epinephrine, but by vasopressin and neurotransmitters, respectively!
| Abbreviation | Name | Function |
| AC | Adenylyl Cyclase | Activated by glucagon receptor, produces cAMP from ATP. |
| cAMP | Cyclic AMP | Activates Protein Kinase A |
| PKA | Protein Kinase A | Mediates the effects of mainly glucagon (in liver) and epinephrine (in muscle), but also vasopressin in the kidney and neurotransmitters in the brain |
| HSL | Hormone-sensitive lipase | A lipase found in adipocytes. Catalyses DAG -> MAG + FFA |
| AQP2 | Aquaporin 2 | A water channel in the kidney used for water reabsorption |
| ACC | Acetyl-CoA carboxylase | Catalyses Acetyl-CoA -> Malonyl-CoA, which inhibits β-oxidation |
| HMG-CoAR | HMG-CoA reductase | Catalyses the rate-limiting step of cholesterol synthesis |
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