Protein Kinase C pathway

Page created on May 13, 2018. Last updated on March 11, 2020 at 17:48

Protein kinase C is activated in the signal pathways of many hormones. The most important ones are acetylcholine, angiotensin II, glutamate, histamine,  vasopressin and oxytoxin. Vasopressin is shown in the figure as an example.

Protein kinase C performs many functions of which we don’t have to know the details of. Some are shown on the figure, but other functions are receptor desensitization, membrane structure regulation, gene expression, immune response cell cyclus, learning and memory.

Abbreviation Name Function
PLC Phospholipase C Catalyses the formation of PIP2 in the cell membrane to IP3 and DAG
PIP2 Phosphatidylinositol 4,5-bisphosphate A membrane lipid. Is cleaved by PLC into IP3 and DAG.
IP3 Inositol triphosphate Travels to the surface of the ER where it binds to and opens the IP3-dependent Ca2+ channel, releasing Ca2+ from the ER into the cytosol
DAG Diacylglycerol Travels along the cell membrane until it binds to PKC
PKC Protein kinase C Activated by DAG and Ca2+, performs many functions in the cell.

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