30. Phaeochromocytoma

Page created on April 4, 2019. Last updated on May 14, 2019 at 17:19

Staining: HE

Organ: Adrenal gland


The whole slide is tumor except for a small part on the lower right side, where we can see normal adrenal cortex.

The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells.

Diagnosis: Phaeochromocytoma

Risk factors:

  • Germ-line mutations in RET, NF1, VHL


These tumors produce catecholamines sporadically, causing paroxysmal hypertensive crises.

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