38. Hydatidiform mole

Page created on April 24, 2019. Last updated on March 15, 2022 at 17:18

Staining: HE

Organ: Placenta?


Both abnormal and normal chorionic villi are present, indicating that this is a partial hydatidiform mole.

The abnormal villi show hydropic swelling, making them much larger than normal villi. They also have a loose, myxomatous and oedematous stroma.

Diagnosis: Partial hydatidiform mole (some teachers say that it’s a complete mole rather than a partial one. See the comments)

Risk factor:

  • Asian countries
  • Women < 20 or > 40


Partial hydatidiform moles usually contain some foetal cells but we do not have to recognize those.

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5 thoughts on “38. Hydatidiform mole”

  1. Hello, are you sure about the partial mole? In the Ivett Skript I´ve read about a complete one:)

    1. Well my teacher said partial, and the slide does show features of partial rather than complete.

  2. Hey, thanks for the great summaries. I just wanted to add what the teacher said in the slide description videos on potepedia.

    In the slide description videos the teacher explains that it is a complete mole.
    – no fetal elements
    – partial wouldn’t be so abnormal (cyst not that big, Trophoblastic proliferation milder or focal)

    1. Added a note about the controversy. Thanks.

      (I imagine in cases like these, where pathologists disagree as to which type it is, they’d probably proceed with immunohistochemistry and molecular diagnosis to determine the type.)

  3. I think its a complete beacuse there are no fetal elements, and it is not a chorioncarcinoma because you can see the villis, in chorioncarcinoma you can only see hypercellular trophoblast areas. In partial mola you can not see this many hypercellular areas ( trophobalst cells) and less oedema.

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