45. Nodular melanoma

Page created on May 8, 2019. Not updated since.

Staining: HE

Organ: Skin


Like the name implies the tumor forms a nodule. The tumor cells are highly atypical, bordering on anaplastic. Some of the tumor cells contain melanin.

Tumor cells are present in the epidermis as well.

Diagnosis: Nodular melanoma


  • Sun exposure


The presence of tumor cells in the epidermis is essential to establish the diagnosis of primary melanoma. If there were no tumor cells there the lesion could have been a melanoma metastasis rather than the primary tumor.

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