49. Giant cell tumor of bone (osteoclastoma)

Page created on May 1, 2019. Not updated since.

Staining: HE

Organ: Bone tumor sampled by curettage


The purplish things are pieces of the tumor. The pinkish things are not.

The tumor pieces are comprised of two types of cell. There are osteoclast-type giant cells, which have large eosinophilic cytoplasm and many nuclei. These cells are not neoplastic; they are reactive cells.

The cells that are between the giant cells are the neoplastic cells. These cells are primitive mesenchymal cells with poorly defined cytoplasm.

Diagnosis: Giant cell tumor of bone

Risk factors:

  • Age 20 – 45


The old name for this tumor is “osteoclastoma”.

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Histopathology slides

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