44. NRDS

Last updated on January 17, 2019 at 17:21

Staining: PAS

Organ: Lung


The lung parenchyme look odd, and there are much fewer (open) alveoli than normal. The alveoli that are present are covered by a hyaline “membrane”.

Diagnosis: Neonatal respiratory distress syndrome


  • Lack of pulmonary surfactant


In NRDS are most alveoli atelectic (collapsed), which is why so few alveoli are visible and why the lung parenchyme looks “denser”. The atelectasis damages the alveolo-capillary membrane, increasing the permeability of it, which allows fibrous exudate to enter the alveoli. It is this exudate that forms the hyaline membranes.

RBCs enter the alveoli when the alveolo-capillary membrane is damaged.

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