11. Hyalinised glomeruli

Page created on February 27, 2019. Last updated on March 11, 2019 at 19:26

Staining: HE

Organ: Kidney


Four typical signs can be seen:

  1. Most glomeruli contain globular eosinophilic structures. Some glomeruli are unaffected.
  2. The tubulointerstitium is infiltrated by RBCs, lymphocytes and plasma cells
  3. The tubules contain eosinophilic substance, making they look like the thyroid histologically. This process is called thyroidisation.
  4. Arteriolosclerosis of the vessels in the renal sinus

Diagnosis: Hyalinised glomeruli


  • Diabetic nephropathy
  • Chronic pyelonephritis
  • Rapidly progressing glomerulonephritis
  • Glomerulonephritis


Hyalinisation of the glomeruli is the morphology of
the end-stage kidney disease (chronic renal failure), which is often the end-result of the conditions mentioned above.

Despite the loss of many glomeruli some are still normal and functioning, so the kidney still produces some urine.

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