Page created on February 27, 2019. Last updated on March 11, 2019 at 19:26
Four typical signs can be seen:
- Most glomeruli contain globular eosinophilic structures. Some glomeruli are unaffected.
- The tubulointerstitium is infiltrated by RBCs, lymphocytes and plasma cells
- The tubules contain eosinophilic substance, making they look like the thyroid histologically. This process is called thyroidisation.
- Arteriolosclerosis of the vessels in the renal sinus
Diagnosis: Hyalinised glomeruli
- Diabetic nephropathy
- Chronic pyelonephritis
- Rapidly progressing glomerulonephritis
Hyalinisation of the glomeruli is the morphology of
the end-stage kidney disease (chronic renal failure), which is often the end-result of the conditions mentioned above.
Despite the loss of many glomeruli some are still normal and functioning, so the kidney still produces some urine.