Page created on February 20, 2019. Not updated since.
Almost all glomeruli in the slide contain some degree of fibrocellular tissue. Some glomeruli have this tissue in a half-moon-like formation called crescents. The finding of crescents is associated with RPGN.
Diagnosis: Rapidly progressing glomerulonephritis (RPGN)
- Goodpasture syndrome
- Immune complex mediated
- Rheumatic fever
- IgA nephropathy
Crescents are formed by proliferation of parietal cells and by migration of macrophages into the Bowman’s space. They are comprised of macrophages, fibroblasts, fibrosis and possibly necrosis.
Rapidly progressing glomerulonephritis causes rapid renal failure within days. Diagnosis is based on histology.