20. CML-CP smear

Page created on March 13, 2019. Last updated on May 2, 2021 at 20:34

Staining: May Grunwald-Giemsa

Organ: Blood smear


There is a marked increase in the number of WBCs compared to normal. Not only mature cells are visible (neutrophils, basophils, eosinophils), but also immature cells.

Diagnosis: Chronic phase of chronic myeloid leukaemia


  • Philadelphia chromosome (t(9;22))


The CML slide I have is different than the one in class, so there’s no point in an overview picture. The characteristics are the same anyway.

CML involves an extreme proliferation of the myeloid cell line, which includes those cell lines that develop from myeloblasts into basophils, eosinophils and neutrophils (not monocytes). Because of this can we see many immature WBCs in the peripheral blood smear. These immature cells are large, have small cytoplasm and large nuclei.

The cell types you must recognize are mature neutrophils (segmented nucleus) and immature cells.

Protected Area

These images are password-protected due to copyright concerns. Please verify with a password to unlock the content. If you are a medical student in Pécs or feel like you should have access to the content for any other reason, send me an e-mail.

3 thoughts on “20. CML-CP smear”

    1. The title contains the abbreviation MGG, standing for May-Grunwald Giemsa. Thought maybe it would be useful 🙂

Leave a Reply

Inputting your name is optional. All comments are anonymous.

This site uses Akismet to reduce spam. Learn how your comment data is processed.