34. Seminoma

Page created on April 11, 2019. Last updated on May 14, 2019 at 17:37

Staining: HE

Organ: Testis


As with any seminoma is germ cell neoplasia in situ (GCNIS) present. There are two smaller tumor foci and one that is larger. The larger tumor focus is divided by eosinophilic septa, which is responsible for the lobulated macroscopical morphology.

The tumor cells are large, show severe atypia and have very bright cytoplasm due to their high glycogen content. The tumor cells are separated by a lymphocytic stroma.

Diagnosis: Seminoma


  • 30 – 40 year old males


Seminomas never contain necrosis. The high glycogen content of the tumor cells make them PAS positive. The conventional (clear cell) renal cell carcinoma has similar-looking cytoplasm, but those tumor cells wouldn’t be PAS positive.

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