9. Hepatocellular carcinoma in cirrhosis

Page created on February 20, 2019. Last updated on April 26, 2020 at 16:15

Staining: HE

Organ: Liver


There is no healthy liver parenchyme visible.

On the left part of the slides can we see some pseudolobules of varying size and without central veins.

On the rest of the slide can we see large nodules with cells that show pleiomorphism, atypia and mitotic activity. Some of the tumor cells show intranuclear inclusion bodies. Coagulative necrosis is also visible in the in the upper right corner inside the right large nodule.

Diagnosis: Hepatocellular carcinoma (HCC)


  • Alcoholic/viral/metabolic hepatitis -> cirrhosis -> HCC


The pseudolobules indicate that there is cirrhosis present. The larger nodules with atypia and necrosis are nodules of the hepatocellular carcinoma.

Almost all cases of hepatocellular carcinoma develop in cirrhotic livers. The only exception is the fibrolamellar type of HCC.

Protected Area

These images are password-protected due to copyright concerns. Please verify with a password to unlock the content. If you are a medical student in Pécs or feel like you should have access to the content for any other reason, send me an e-mail.

Leave a Reply

Inputting your name is optional. All comments are anonymous.

This site uses Akismet to reduce spam. Learn how your comment data is processed.