Page created on March 6, 2019. Last updated on April 25, 2019 at 19:42
Organ: Lymph node with perinodal fat
Abnormal follicles are visible. These follicles are made up of tumor cells and are therefore called neoplastic follicles. The tumor cells show only mild atypia/pleiomorphism. The neoplastic follicles have broken mantle zone and shows no “starry sky” pattern. The neoplastic follicles infiltrate the perinodal fat tissue.
The tissue between the neoplastic follicles appears compressed.
Diagnosis: Follicular lymphoma
- t(14;18) translocation – fusion of BCL2 and IgH genes
The translocation of the IgH gene (with its highly active promoter region) into the BCL2 (an antiapoptotic protein) on chromosome 18 causes the BCL2 gene to be overexpressed. These cells therefore have high antiapoptotic activity. Due to this is there no apoptosis in the follicles, so the “starry sky” pattern not visible.